Journal of Organic Chemistry p. 1688 - 1691 (1984)
Update date:2022-08-04
Topics:
Snider, Barry B.
Cartaya-Marin, Claudia P.
(+/-)-Nitramine (1a) was synthesized in seven steps from methylenecyclohexane in 33percent overall yield.A three-step sequence was developed from methylenecyclohexane to aldehyde 4 in which methyl α-chloroacrylate was used as a ketene equivalent in the ene reaction.Aldehyde 4 was converted to nitrone 3 which cyclized to a 2.5:1 mixture of 2 and 9.Hydrogenolysis of 2 gave 1a.Lewis acid catalyzed cyclization of 4 gave a 3.5:1 mixture of hydrindanones 13 and 14 at 25 deg C and a 12:1 mixture of 13 and 14 at -20 deg C.
View MoreShenzhen HwaGen Pharmaceutical Co., Ltd
website:http://www.rafflespt.com
Contact:+86-752-5538396
Address:Guangdong Huizhou China
Chongqing Rong＆Quan Pharmaceutical Technology Co. , Ltd.
Contact:86-023-65268721
Address:No. 7, Manshanhong Village, Pingdingshan, Shapingba District, Chongqing Province, China
Chengdu CSH Pharmaceutical Co.,ltd
Contact:+86-(28)-85321971
Address:Block B,New Hope Int. Tian Fu New District, Chengdu, Sichuan, China
FREEBARQUE DEVELOPMENT GROUP LIMITED
Contact:+86(0)10-5109 5335 or 5109 5345
Address:Room602,Block1-B,LINGDI OFFICE,NO.13 BEIYUAN ROAD
Changzhou Anyi Biochem Co., Ltd.(expird)
Contact:+86-519-88836158
Address:no,51 caoda
Doi:10.1002/1522-2675(200211)85:11<3657::AID-HLCA3657>3.0.CO;2-A
(2002)Doi:10.1016/j.cclet.2021.02.061
(2021)Doi:10.1021/jo01160a020
(1948)Doi:10.1016/S0040-4039(00)99907-6
(1984)Doi:10.1021/jm00372a016
(1984)Doi:10.1021/jo01070a051
(1961)
