Journal of Medicinal Chemistry p. 792 - 799 (1984)
Update date:2022-08-04
Topics:
Carre, Marie-Christiane
Youlassani, Alphonse
Caubere, Paul
Saint-Aubin-Floch, Anne
Blanc, Marie
Advenier, Charles
A new family of β-blocking drugs is described.The originality of the new molecules lies in their functionalized hydrophobic folded structure, the basic part of which contains a benzocyclobutene ring.Excellent β2-blocker selectivity has been obtained with some of these compounds.Interestingly, this selectivity was not modified toward β1-blocker activity by introduction of the usual β1 inducer groups.
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