Synthesis of a Novel Series of (Aryloxy)propanolamines: New Selective β2-Blocking Agents

Article abstract of DOI:10.1021/jm00372a016

A new family of β-blocking drugs is described.The originality of the new molecules lies in their functionalized hydrophobic folded structure, the basic part of which contains a benzocyclobutene ring.Excellent β₂-blocker selectivity has been obtained with some of these compounds.Interestingly, this selectivity was not modified toward β₁-blocker activity by introduction of the usual β₁ inducer groups.