Chemical and Pharmaceutical Bulletin p. 247 - 255 (1995)
Update date:2022-08-04
Topics:
Seki
Takezaki
Ohuchi
Ohuyabu
Tanimoto
Yamaguchi
Saitoh
Ishimori
Yasuda
A series of phenoxypropanolamines having a hydrazinopyridazinyl moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Some of them exhibited both activities. In particular, compound 20k is a candidate for clinical use due to its hypotensive activity, equal to that of hydralazine, and its β-blocking activity, 2.7-fold more potent than that of propranolol.
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