Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E2

DOI: 10.1021/acs.orglett.8b01578

Source and publish data:

Organic Letters p. 4020 - 4022 (2018)

Update date:2022-08-04

Topics:

Authors:

Boer, Robert E.

Giménez-Bastida, Juan Antonio

Boutaud, Olivier

Jana, Somnath

Schneider, Claus

Sulikowski, Gary A.

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Article abstract of DOI:10.1021/acs.orglett.8b01578

The total synthesis of hemiketal E₂ (HKE₂) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE₂.

Full text of DOI:10.1021/acs.orglett.8b01578

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