Cross-coupling of alkyl halides with aryl Grignard reagents catalyzed by a low-valent iron complex

DOI: 10.1002/anie.200460504

Source and publish data:

Angewandte Chemie - International Edition p. 3955 - 3957 (2004)

Update date:2022-08-04

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Authors:

Martin, Ruben

Fuerstner, Alois

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Article abstract of DOI:10.1002/anie.200460504

A striking reversal of the usual reactivity pattern of aryl Grignard reagents is observed for reactions in the presence of catalytic amounts of the "bare" ferrate complex [Li(tmeda)]₂[Fe(C₂H ₄)₄] (1). Highly reduced iron-magnesium clusters may play a decisive role in the exceptionally facile and chemoselective cross-coupling reaction with alkyl halides (see scheme).

Full text of DOI:10.1002/anie.200460504

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