ChemMedChem p. 898 - 903 (2013)
Update date:2022-08-05
Topics:
Steiner, Michel A.
Gatfield, John
Brisbare-Roch, Catherine
Dietrich, Hendrik
Treiber, Alexander
Jenck, Francois
Boss, Christoph
Stress relief: Orexin neuropeptides regulate arousal and stress processing through orexin receptor type1 (OXR-1) and 2 (OXR-2) signaling. A selective OXR-1 antagonist, represented by a phenylglycine-amide substituted tetrahydropapaverine derivative (ACT-335827), is described that is orally available, penetrates the brain, and decreases fear, compulsive behaviors and autonomic stress reactions in rats. Copyright
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