Synthesis of diazipine and [3H]diazipine: Novel dihydropyridines as photoaffinity probes of calcium channels

DOI: 10.1248/cpb.39.1860

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1860 - 1862 (1991)

Update date:2022-08-05

Topics:

Authors:

Taki Taki

Kuniyasu

Nakayama

Kanaoka Kanaoka

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.39.1860

Diazipine and [³H]diazipine were synthesized as new 1,4-dihydropyridine photoaffinity ligands containing a phenyldiazirine group. After simple high performance liquid chromatography separation, both compounds were purified in good overall yields. [³H]Diazipine (21.2 Ci/mmol) was synthesized in two steps from commercially available [³H]ethanolamine. Diazipine competitively inhibited [³H]PN200-110 binding to the calcium channel of cardiac membranes with high affinity.

Full text of DOI:10.1248/cpb.39.1860

NII-Electronic Library Service

Products guided by the article

Product name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-[2-(trifluoromethyl)phenyl]-, 2-aminoethyl ethyl ester

Cas No:90105-80-9

R&D Labs maybe for 90105-80-9

Ring Specialty Chemicals Inc.

website:http://www.ringchemicals.com/

Contact:+1-416-493-6870

Address:Toronto, Canada
Zhejiang Tianyu Pharmaceutical Co., Ltd.

Contact:+86-576-84177669, 89189665,89189688,84168770

Address:Jiangkou Development Zone, Huangyan, Taizhou City, Zhejiang
CHINA MEHECO CORPORATION

Contact:+86-10-67147360/67107388

Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
Hangzhou Ledun Technology Co.,Ltd.

Contact:86-571-18767088918

Address:No.6 street,XiaSha,Hangzhou,China.
Simagchem Corporation

website:http://www.simagchem.com

Contact:+86-592-2680277

Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China

Relevant to this article

General and efficient indole syntheses based on catalytic amination reactions

Doi:10.1021/ol047649j
(2005)
Mechanistic insight into the protonolysis of the Pt-C bond as a model for C-H bond activation by platinum(II) complexes

Doi:10.1021/om060217n
(2006)
Reaction of dibenzylphosphine oxide with α,β-unsaturated O-methyloximes

Doi:10.1023/A:1023902621846
(2003)
Strategic Trimethylsilyldiazomethane Insertion into pinB-SR Followed by Selective Alkylations

Doi:10.1021/acs.orglett.6b01840
(2016)
Palladium complexes with chiral diphospholane ligands: Comparative catalytic properties and analysis of (η³-allyl)palladium species

Doi:10.1002/ejic.200400312
(2004)
From the ganglioside GQ1bα to glycomimetic antagonists of the myelin- associated glycoprotein (MAG)

Doi:10.2533/chimia.2010.17
(2010)

Article Doi