Synthesis of diazipine and [3H]diazipine: Novel dihydropyridines as photoaffinity probes of calcium channels

DOI: 10.1248/cpb.39.1860

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1860 - 1862 (1991)

Update date:2022-08-05

Topics:

Authors:

Taki Taki

Kuniyasu

Nakayama

Kanaoka Kanaoka

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Article abstract of DOI:10.1248/cpb.39.1860

Diazipine and [³H]diazipine were synthesized as new 1,4-dihydropyridine photoaffinity ligands containing a phenyldiazirine group. After simple high performance liquid chromatography separation, both compounds were purified in good overall yields. [³H]Diazipine (21.2 Ci/mmol) was synthesized in two steps from commercially available [³H]ethanolamine. Diazipine competitively inhibited [³H]PN200-110 binding to the calcium channel of cardiac membranes with high affinity.

Full text of DOI:10.1248/cpb.39.1860

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