Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes

DOI: 10.1021/jm300884k

Source and publish data:

Journal of Medicinal Chemistry p. 7828 - 7840 (2012)

Update date:2022-08-04

Topics:

Authors:

Ohtake, Yoshihito

Sato, Tsutomu

Kobayashi, Takamitsu

Nishimoto, Masahiro

Taka, Naoki

Takano, Koji

Yamamoto, Keisuke

Ohmori, Masayuki

Yamaguchi, Marina

Takami, Kyoko

Yeu, Sang-Yong

Ahn, Koo-Hyeon

Matsuoka, Hiroharu

Morikawa, Kazumi

Suzuki, Masayuki

Hagita, Hitoshi

Ozawa, Kazuharu

Yamaguchi, Koji

Kato, Motohiro

Ikeda, Sachiya

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Article abstract of DOI:10.1021/jm300884k

Inhibition of sodium glucose cotransporter 2 (SGLT2) has been proposed as a novel therapeutic approach to treat type 2 diabetes. In our efforts to discover novel inhibitors of SGLT2, we first generated a 3D pharmacophore model based on the superposition o

Full text of DOI:10.1021/jm300884k

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