Bioorganic and Medicinal Chemistry Letters p. 1595 - 1600 (1997)
Update date:2022-08-04
Topics:
Quan
Wityak
Dominguez
Duncia
Kettner
Ellis
Liauw
Park
Santella
Knabb
Thoolen
Weber
Wexler
Thrombin is a serine protease that plays an important role in the blood coagulation cascade, and is a target enzyme for new therapeutic agents. Ac- (D)-Phe-Pro-boroArg-OH (DuP 714) was found to be a highly effective thrombin inhibitor. In order to reduce the peptidic nature of DuP 714, we have designed a series of novel biaryl substituted alkylboronate esters as potent thrombin inhibitors. The most potent compounds have subnanomolar affinity for thrombin.
View MoreContact:Tel:+86-29-88764861 Fax:+86-29-88764861
Address:Rm#2107, Block A, Epin Meidao Building, Gaoxin Rd, Hi-Tech Zone, Xi’an, China
TIANJIN GST CHEMICAL TECHNOLOGY CO., LTD
Contact:+86-22-25210964
Address:Room. 208, No. -12-C, No. 13, Xinbei Road, Tanggu District, New Haixin Area, Tianjin City, China
ALPHA PHARMACEUTICAL CO，LTD JIANGSU
Contact:+86-527-84829968,+86-527-84829998
Address:suqian city
zhangjiagang bonded areas banggao co;ltd
website:http://www.shunchangchem.com
Contact:0086-13921972933
Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
Contact:+86-13914766747
Address:Floors 21&22, Jin Cheng Tower, No. 216 Middle Longpan Road, Nanjing
Doi:10.1002/ejoc.201801847
(2019)Doi:10.1016/j.tet.2011.07.064
(2011)Doi:10.1016/S0040-4039(00)99824-1
(1984)Doi:10.1021/ja00320a045
(1984)Doi:10.1002/chem.201502357
(2015)Doi:10.1002/adfm.201603408
(2016)
