Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activation

DOI: 10.1016/j.bmc.2006.04.039

Source and publish data:

Bioorganic and Medicinal Chemistry p. 5489 - 5502 (2006)

Update date:2022-07-29

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Authors:

Hosoda, Shinnosuke

Tanatani, Aya

Wakabayashi, Ken-ichi

Makishima, Makoto

Imai, Keisuke

Miyachi, Hiroyuki

Nagasawa, Kazuo

Hashimoto, Yuichi

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Article abstract of DOI:10.1016/j.bmc.2006.04.039

Ligands possessing dual vitamin D₃ (VD₃)-agonistic and androgen-antagonistic activities with various activity spectra were prepared based on a substituted 3,3-diphenylpentane (DPP) skeleton. Among the compounds, (R,S)-DPP-1023 [(R,S)

Full text of DOI:10.1016/j.bmc.2006.04.039

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