Journal of Organic Chemistry p. 2795 - 2799 (1984)
Update date:2022-08-05
Topics:
Olofson, R. A.
Abbott, Duain E.
Primary alkyl chlorides (R-Cl) are easily isolated in excellent yield after treatment of the appropriate N-alkylpiperidines (R-NC5H10) with α-chloroethyl chloroformate.The method is exemplified by the conversion of a variety of alkylpiperidines, including systems with other sensitive functionalities, to the respective chlorides in yields varying from 90 to 97percent.The potential significance of this process in drug congener preparation and in total synthesis is outlined.Similar fragmentations of N-sec-alkylpiperidines are described.
View MoreShanghai Sinofluoro Scientific Co., Ltd
Contact:+86-21-64279360
Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
Chengdu Chengnuo New-Tech Co., Ltd
Contact:0086-028-85749078
Address:4 Jiuyang road,Jiulong industrial port,Chengdu, China
Wuhan Jadechem International Trade Co.,Ltd.
website:http://www.jadechem-intl.com
Contact:+86-27-83527060
Address:Room502,Building C11,Software new city No.9,Huacheng Avenue,East Lake High-tech development zone,Wuhan,Hubei,China
Shanghai Sinofluoro Scientific Co., Ltd
Contact:+86-21-64279360
Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
NINGXIA DARONG CHEMICALS & METALLURGY CO.,LTD.
Contact:86-952-2179751
Address:Darong Road, Dawukou, Shizuishan, Ningxia 753001, China
Doi:10.1248/cpb.10.372
(1962)Doi:10.1016/j.tetlet.2020.152016
(2020)Doi:10.1021/ja01872a029
(1939)Doi:10.1039/b605912k
(2006)Doi:10.1002/jps.2600550717
(1966)Doi:10.1016/S0040-4039(00)96047-7
(1987)