The Synthesis of Isotopically Labeled β-Adrenergic Agents by Reductive Amination: Unexpected Site of Deuterium Incorporation

DOI: 10.1021/jo00191a018

Source and publish data:

Journal of Organic Chemistry p. 3138 - 3141 (1984)

Update date:2022-07-30

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Authors:

Asscher, Yael

Ferraiolo, Bobbe

Castagnoli, Neal

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Article abstract of DOI:10.1021/jo00191a018

The reduction of imines derived from the condensation of (R)-norepinephrine and certain methyl ketones with D2 over a Pt catalyst leads to the formation of deuterium labeled products in which the deuterium is located exclusively in the methyl substituent.

Full text of DOI:10.1021/jo00191a018

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