Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains

DOI: 10.1021/jm060320e

Source and publish data:

Journal of Medicinal Chemistry p. 5501 - 5512 (2006)

Update date:2022-08-05

Topics:

Authors:

Xu, Jianfeng

Yang, Zhenjun

Dammermann, Werner

Zhang, Liangren

Guse, Andreas H.

Zhang, Li-He

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Article abstract of DOI:10.1021/jm060320e

Novel analogues of cADPR with adenine as base and ether (10a) or different alkane chain (10b-d) substitutions of the northern ribose were synthesized from protected imidazole nucleoside 1 in good yields. The pharmacological activities of cyclic inosine di

Full text of DOI:10.1021/jm060320e

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