Journal of Pharmaceutical Sciences p. 850 - 852 (1984)
Update date:2022-07-29
Topics:
Kadaba
A series of 1,5-diaryl-Δ2-1,2,3-triazolines has been synthesized and evaluated for the first time as potential anticonvulsant agents using the standard subcutaneous pentylenetetrazol seizure threshold and maximal electroshock seizure tests. Out of the 31 triazolines that were screened, 11 exhibited moderate anticonvulsant activity; 9 of the compounds afforded protection against pentylenetetrazol-induced seizures, while two antagonized electrically induced convulsions.
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Doi:10.1021/jo01029a082
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