Bioorganic and Medicinal Chemistry Letters p. 3168 - 3172 (2008)
Update date:2022-08-05
Topics:
Wang, Haixia
Ruan, Zheming
Li, James J.
Simpkins, Ligaya M.
Smirk, Rebecca A.
Wu, Shung C.
Hutchins, Robert D.
Nirschl, David S.
Van Kirk, Katy
Cooper, Christopher B.
Sutton, James C.
Ma, Zhengping
Golla, Rajasree
Seethala, Ramakrishna
Salyan, Mary Ellen K.
Nayeem, Akbar
Krystek Jr., Stanley R.
Sheriff, Steven
Camac, Daniel M.
Morin, Paul E.
Carpenter, Brian
Robl, Jeffrey A.
Zahler, Robert
Gordon, David A.
Hamann, Lawrence G.
Several series of pyridine amides were identified as selective and potent 11β-HSD1 inhibitors. The most potent inhibitors feature 2,6- or 3,5-disubstitution on the pyridine core. Various linkers (CH2SO2, CH2S, CH2 View More
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