Intercalator amino acids: Synthesis of heteroaryl alanines

Article abstract of DOI:10.1016/0957-4166(94)80088-X

Stereoselective alkylation of (S)-(-)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolinone with 2-chloromethylquinoline, 2-chloromethylquinoxaline and 5-chloromethyl-1,10-phenanthroline, followed by hydrolysis, afforded the corresponding (S)-(+)-α-amino acids with high enantiomeric excess.