Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors

DOI: 10.1016/j.bmcl.2009.10.118

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 294 - 298 (2010)

Update date:2022-08-02

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Authors:

Angibaud, Patrick

Emelen, Kristof Van

Decrane, Laurence

Brandt, Sven van

Holte, Peter ten

Pilatte, Isabelle

Roux, Bruno

Poncelet, Virginie

Speybrouck, David

Queguiner, Laurence

Gaurrand, Sandrine

Marien, Ann

Floren, Wim

Janssen, Lut

Verdonck, Marc

Dun, Jacky van

Gompel, Jacky van

Gilissen, Ron

Mackie, Claire

Jardin, Marc Du

Peeters, Jozef

Noppe, Marc

Hijfte, Luc Van

Freyne, Eddy

Page, Martin

Janicot, Michel

Arts, Janine

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Article abstract of DOI:10.1016/j.bmcl.2009.10.118

Pursuing our efforts in designing 5-pyrimidylhydroxamic acid anti-cancer agents, we have identified a new series of potent histone deacetylase (HDAC) inhibitors. These compounds exhibit enzymatic HDAC inhibiting properties with IC₅₀ values in t

Full text of DOI:10.1016/j.bmcl.2009.10.118

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