Synthesis, cytotoxicity, and hemolytic activity of 6′-O-substituted dioscin derivatives

Article abstract of DOI:10.1016/j.carres.2007.09.004

Dioscin derivatives (1-12) with a variety of substitutions at the 6′-OH of the chacotriosyl residue and the 3′,6′-anhydrosaponin derivatives (26, 30, and 32) were synthesized. All these derivatives showed much lower cytotoxicity than that of the parent di