Benzoquinazoline Inhibitors of Thymidylate Synthase: Methylenediamino-Linked Aroylglutamate Derivatives

DOI: 10.1021/jm00032a019

Source and publish data:

Journal of Medicinal Chemistry p. 838 - 844 (1994)

Update date:2022-08-03

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Authors:

Pendergast, William

Dickerson, Scott H.

Dev, Inderjit K.

Ferone, Robert

Duch, David S.

Smith, Gary K.

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Article abstract of DOI:10.1021/jm00032a019

Syntheses of several new inhibitors of thymidylate synthase (TS) structurally related to folic acid are described in which the pterin portion of the folate molecule is replaced by a benzoquinazoline moiety, but which retain the natural methyleneamino l

Full text of DOI:10.1021/jm00032a019

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