Journal of the Chemical Society. Perkin transactions I p. 715 - 718 (1996)
Update date:2022-08-04
Topics:
Kawanaka, Yasufumi
Ono, Naoya
Yoshida, Yukio
Okamoto, Sentaro
Sato, Fumie
Starting with commercially available (3S,4R)-3-(methoxymethyloxy)-2-methylidene-4-siloxycyclopentanone 2, useful 6-keto-prostaglandin intermediates 1 have been prepared in good yields by a sequence of reactions which includes treatment with NaBr in the presence of BF3·OEt2, Pd-catalysed coupling of the resulting 2-bromomethyl-4-siloxycyclopent-2-enone 3 with the alkenylborane 4 or 9 and conversion of the alkenyl moiety into an epoxy and then into a keto group. The synthesis of 6-keto-PGE1, ornoprostil and Δ2-trans-6-keto-PGE1 by using 1 is also described.
View MoreAUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD
Contact:+86-25-86883560 15951806178
Address:14 Dayingbi, Zhujiang Rd. East, Nanjing, Jiangsu, China.
Zhejiang Newfine Industry Co.,Ltd.
Contact:+86-573-82262042
Address:No.225,Dongqing Road, garoms@163.com
Suzhou Health Chemicals Co., Ltd.
website:http://www.healthchems.com
Contact:13776257979
Address:No. 338, Jingang Avenue,
Contact:86-25-58619180
Address:Nanjing High-Tech Zone 10 Xinghuo Road Pukou District Nanjing, Jiangsu 210061 The People's Republic of China
Hangzhou Eastbiopharm Co.,Ltd.
Contact:+86-571-88931780
Address:Hangzhou,China
Doi:10.1039/d0ra02673e
(2020)Doi:10.1055/s-1987-28103
(1987)Doi:10.1055/s-1987-28080
(1987)Doi:10.1021/jo01377a008
(1954)Doi:10.3987/COM-08-S(F)90
(2009)Doi:10.1016/s0040-6031(98)00389-x
(1998)
