An Efficient Method for the Preparation of Carbapenem Derivatives with C-2 Carbon Side Chains from PS-5 and OA-6129 Compounds

DOI: 10.1039/c39840001513

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Journal of the Chemical Society. Chemical communications p. 1513 - 1514 (1984)

Update date:2022-08-04

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Authors:

Yoshioka, Takeo

Yamamoto, Ken-ichi

Shimauchi, Yasutaka

Fukagawa, Yasuo

Ishikura, Tomoyuki

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Article abstract of DOI:10.1039/c39840001513

Treatment of S-oxides of PS-5 and OA-6129 esters with nitromethane gives 2-(nitromethyl)carbapenems which are converted into nitrile oxides leading to isoxazolyl, isoxazolinyl, or isoxadiazolinyl derivatives.

Full text of DOI:10.1039/c39840001513

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