Phosphorus, Sulfur and Silicon and the Related Elements p. 1087 - 1102 (2006)
Update date:2022-08-04
Topics:
Attaby, Fawzy A.
Elghandour
Ali
Ibrahem, Yasser M.
1-(3-Amino-6-methyl-4-pyridin-3-yl-1H-pyrazolo[3,4-b]pyridin-5-yl)ethano ne (3) was obtained in very pure state and used as a good starting material for the present study. It diazotized to give the corresponding diazonium salt 9 and also reacted with phenyl isothiocyanate to give the corresponding thiourea derivative 4. Compound 4 was used for the preparation of thiazole derivatives 5-8 via the reaction with active halogen-containing compounds. On the other hand, compound 9 coupled with several active -CH2- containing compounds to afford the corresponding triazine derivatives 10-17. Considering the data from IR, 1H NMR, mass spectra, and elemental analyses, the chemical structures of the newly synthesized heterocyclic compounds were elucidated. Cytotoxicity, anti-HSV1, and anti-HAV-MBB activity were evaluated for the newly synthesized heterocyclic compounds. Copyright Taylor & Francis Group, LLC.
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