Tetrahedron p. 3087 - 3094 (1984)
Update date:2022-08-04
Topics:
Chantreux, Dominique
Gamet, Jean-Paul
Jacquier, Robert
Verducci, Jean
The use of 2-(diphenylphosphino)ethyl group for carboxyl-protection of amino acids or peptides is described.This group is easily introduced by esterification using 2-(diphenylphosphino)ethanol in the presence of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine.These Dppe esters are stable under the standard conditions for peptide synthesis.Deprotection is carried out under mild conditions by quaternisation using methyl iodide followed by a β-elimination induced by fluoride ion or potassium carbonate.
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