Tetrahedron p. 3087 - 3094 (1984)
Update date:2022-08-04
Topics:
Chantreux, Dominique
Gamet, Jean-Paul
Jacquier, Robert
Verducci, Jean
The use of 2-(diphenylphosphino)ethyl group for carboxyl-protection of amino acids or peptides is described.This group is easily introduced by esterification using 2-(diphenylphosphino)ethanol in the presence of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine.These Dppe esters are stable under the standard conditions for peptide synthesis.Deprotection is carried out under mild conditions by quaternisation using methyl iodide followed by a β-elimination induced by fluoride ion or potassium carbonate.
View MoreTaizhou Shengxing Chempharm Co.,Ltd
Contact:+86-576-88516600
Address:Yantou Chemical Zone Jiaojiang Taizhou Zhejiang China
Huangshi Shennong Chemical Technology Co., Ltd
Contact:+86-714-3072290
Address:Eastern industrial park , Tieshan district , Huangshi city ,Hubei province , China
Chongqing KonAo Health Co.,Ltd
Contact:13687578375
Address:wuhan hubei china
Contact:+86-574-89075960
Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
Huludao Tianqi Shengye Chemical Co.,Ltd.
Contact:0086 429 2075777
Address:Area B,Shipbuilding Industry Park,Beigang District,Huludao City,Liaoning prov.,China
Doi:10.1007/BF00905703
(1963)Doi:10.1021/ol062556i
(2006)Doi:10.1016/j.ica.2006.07.106
(2007)Doi:10.1016/j.tetlet.2007.01.134
(2007)Doi:10.1016/j.tet.2020.131312
(2020)Doi:10.1134/S1070363206040074
(2006)
