Synthesis and antiaggregator activity of some new derivatives of 4H-benzopyran-4-one

Article abstract of DOI:10.1016/0223-5234(96)88270-5

A series of 2-<2-alkyl-1H-benzimidazol-5(6)-yl>-4H-1-benzopyran-4-one analogues 7a-7e was synthesized by the reaction with 3',4'-diaminoflavone and aliphatic carboxylic acids. 3',4'-Diaminoflavone 6 was prepared via the reduction of 2-(4-amino-3-nitrophenyl)-4H-1-benzopyran-4-one 5a.The compounds 7a-e and 14a-f were tested in vitro for their inhibitory activities against human platelet aggregation induced by collagen, ADP and A23187.The compound with a COOR group as a side chain, 2-(2-akyloxycarbonyl-2,3-dihydro-1,4-benzodioxin -6-yl)-4H-1-benzopyran-4-one 14a-f, haspotent activity, and so compound 13 was also prepared as an analogue of series 14 and tested for its antiaggregator activity. 4H-1-benzopyran-4-one/ benzodioxane/ benzimidazole/ human platelet/ aggregation