Synthetic Communications p. 1883 - 1891 (2020)
Update date:2022-08-03
Topics:
Gutam, Madhu
Mokenapelli, Sudhakar
Yerrabelli, Jayaprakash Rao
Banerjee, Somesh
Roy, Partha
Chitneni, Prasad Rao
A series of new flavanone-triazole hybrids (7a–m) were synthesized from flavanone oximes (6a–c) via multistep synthetic strategy, involving Cu (I) catalyzed azide, alkyne 1,3-dipolar cycloaddition by Click reaction. All the synthesized compounds were tested for their cytotoxicity against HCT-15, HeLa, NCI-H522, and HEK-293 (normal cell line) cell lines. Compounds 6a, 7a, 7b, 7d, 7e, 7j, and 7m showed the significant cytotoxicity, wherein compound 7b showed potential cytotoxicity against NCI-H522 cell line and compounds 6a and 7a were offensive with HEK-293 in their toxicity profile.
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