Journal of Organic Chemistry p. 3620 - 3627 (2004)
Update date:2022-08-02
Topics:
Nelson, Todd D.
LeBlond, Carl R.
Frantz, Doug E.
Matty, Louis
Mitten, Jeffrey V.
Weaver, Damian G.
Moore, Jeffrey C.
Kim, Jaehon M.
Boyd, Russell
Kim, Pei-Yi
Gbewonyo, Kodzo
Brower, Mark
Sturr, Michael
McLaughlin, Kathleen
McMasters, Daniel R.
Kress, Michael H.
McNamara, James M.
Dolling, Ulf H.
The concise synthesis of a potent thrombin inhibitor was accomplished by a mild lactone aminolysis between an orthogonally protected bis-benzylic amine and a diastereomerically pure lactone. The lactone was synthesized by the condensation of L-proline met
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