CHEMICAL SYNTHESIS OF PHOSPHORYLATED TETRAACYL DISACCHARIDE CORRESPONDING TO A BIOSYNTHETIC PRECURSOR OF LIPID A

Article abstract of DOI:10.1016/S0040-4039(01)81258-2

A total synthesis of 2,2'-N; 3,3'-O-tetraquis<(R)-3-hydroxytetradecanoyl>-β(1-6)-D-glucosamine disaccharide 1,4'-diphosphate is described.This is the first confirmation of the fundamental structure of lipid A since the synthetic compound exhibited most of the characteristic biological activities of natural endotoxin.