NITROGEN ALKYLATION OF SCHIFF BASES AND AMIDINES AS A ROUTE TO N-ALKYL AMINO ACIDS

DOI: 10.1016/0040-4039(84)80096-9

Source and publish data:

Tetrahedron Letters p. 3651 - 3654 (1984)

Update date:2022-08-05

Topics:

Authors:

O'Donnell, Martin J.

Bruder, William A.

Daugherty, Byron W.

Liu, Deshan

Wojciechowski, Krzisztof

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Article abstract of DOI:10.1016/0040-4039(84)80096-9

Schiff base and amidine esters 3 are alkylated and then hydrolyzed to yield N-alkyl amino acids 4 in 41-75percent yield with hight to complete retention of optical activity.

Full text of DOI:10.1016/0040-4039(84)80096-9

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