Development of an efficient large-scale synthesis for a 4 H-imidazo[5,1- c ][1,4]benzoxazine-3-carboxamide derivative for depression and anxiety

Article abstract of DOI:10.1021/op100103v

The development and scale-up of an optimized synthesis for a novel drug candidate for depression and anxiety is presented. The updated synthesis represents a convergent and efficient four-stage approach to the API, overcoming high cost of goods (COG), gen