Futher Studies on Aplyronine A, an Antitumor Substance Isolated from the Sea Hare Aplysia kurodai

Article abstract of DOI:10.1016/S0040-4039(00)61369-2

By a series of reactions aplyronine A (1) an antitumor substance of marine origin was transformed into six fragments, and their structures were characterized by spectroscopic methods.Relative stereochemistry of four contiguous chiral centers (C29-C32) in 1 was established and that of three contiguous chiral centers (C23-C25) in 1 was deduced on the basis of the 1H NMR spectral analysis of the fragment 8 and the derived acetonide 9, respectively.