Sculpting the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve recognition by herpes thymidine kinase

DOI: 10.1021/ja0688732

Source and publish data:

Journal of the American Chemical Society p. 6216 - 6222 (2007)

Update date:2022-08-05

Topics:

Authors:

Comin, Maria J.

Agbaria, Riad

Ben-Kasus, Tsipi

Huleihel, Mahmoud

Liao, Chenzhong

Sun, Guangyu

Nicklaus, Marc C.

Deschamps, Jeffrey R.

Parrish, Damon A.

Marquez, Victor E.

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Article abstract of DOI:10.1021/ja0688732

The replacement of the furanose ring by a cyclopentane in nucleosides generates a group of analogues known generically as carbocyclic nucleosides. These compounds have increased chemical and enzymatic stability due to the absence of a true glycosyl bond t

Full text of DOI:10.1021/ja0688732

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