A NEW CLASS OF CONDENSING REAGENTS FOR RAPID INTERNUCLEOTIDE BOND FORMATION IN THE PHOSPHOTRIESTER APPROACH AND PREPARATION OF N3-BENZOYLTHYMIDINE AS A KEY INTERMEDIATE IN OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS

DOI: 10.1016/0040-4039(84)80055-6

Source and publish data:

Tetrahedron Letters p. 4019 - 4022 (1984)

Update date:2022-08-05

Topics:

Authors:

Matsuzaki, Jun-ichi

Hotoda, Hitoshi

Sekine, Mitsuo

Hata, Tujiaki

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Article abstract of DOI:10.1016/0040-4039(84)80055-6

Rapid internucleotide bond formation in the phosphotriester approach has been achieved in high yield by use of bis(2,4,6-trihalophenyl)phosphorochloridates (TCP and TBP) as new condensing reagents and the benzoyl group as the N³-imide protecting group of thymidine.

Full text of DOI:10.1016/0040-4039(84)80055-6

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