A NEW CLASS OF CONDENSING REAGENTS FOR RAPID INTERNUCLEOTIDE BOND FORMATION IN THE PHOSPHOTRIESTER APPROACH AND PREPARATION OF N3-BENZOYLTHYMIDINE AS A KEY INTERMEDIATE IN OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS

DOI: 10.1016/0040-4039(84)80055-6

Source and publish data:

Tetrahedron Letters p. 4019 - 4022 (1984)

Update date:2022-08-05

Topics:

Authors:

Matsuzaki, Jun-ichi

Hotoda, Hitoshi

Sekine, Mitsuo

Hata, Tujiaki

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(84)80055-6

Rapid internucleotide bond formation in the phosphotriester approach has been achieved in high yield by use of bis(2,4,6-trihalophenyl)phosphorochloridates (TCP and TBP) as new condensing reagents and the benzoyl group as the N³-imide protecting group of thymidine.

Full text of DOI:10.1016/0040-4039(84)80055-6

Products guided by the article

Product name:Dithiophosphoric acid O-{(2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester

Cas No:94219-34-8

R&D Labs maybe for 94219-34-8

Hebei Lead Bio-Chemicals Co., Ltd.

website:http://www.ldbiochem.com

Contact:+86-311-87826503

Address:481, Heping West Road, Shijiazhuang,China
Shanghai united Scientific Co.,Ltd.

Contact:+86-21-53535353

Address:28F No.900 huaihai Road Shanghai China
YingYing Pharmaceutical Co.,Ltd

Contact:86-18854126208

Address:55#, yingxiongshan road
Lonzeal Pharmaceuticals Co., Ltd.

website:http://www.lonzeal.com

Contact:+86-13381011962

Address:RM 801, Yue MOMA, No. 26 Anningzhuang Rd. Haidian District, Beijing, China
Shanghai Norky Pharmaceutical Co., LTD.

website:http://www.norkypharm.com

Contact:86-21-61075300

Address:1165 Jiangning Road, Office 1502, Shanghai, China

Relevant to this article

Nanofibers from self-assembly of an aromatic facial amphiphile with oligo(ethylene oxide) dendrons

Doi:10.1039/b617404c
(2007)
New synthetic route to substituted dihydroazulene photoswitches

Doi:10.1039/c1ob06059g
(2011)
An acid-catalyzed formal allylic C-H oxidation of aryl cycloalkenes with N-propylthiosuccinimide

Doi:10.1021/ol200261a
(2011)
Multiple sonogashira reactions of polychlorinated molecules. Synthesis and photophysical properties of the first pentaalkynylpyridines

Doi:10.1021/ol2000183
(2011)
Molecular modeling based approach, synthesis and in vitro assay to new indole inhibitors of hepatitis C NS3/4A serine protease

Doi:10.1016/j.bmc.2010.11.017
(2011)
On/off electrochemical switches based on quinone-bisketals

Doi:10.1039/c0cc04388e
(2011)

Article Doi