Tetrahedron Letters p. 1265 - 1268 (1993)
Update date:2022-07-30
Topics: Synthesis Stereoselective Hydroboration Experimental
Brown, Herbert C.
Salunkhe, Ashok M.
A highly stereoselective synthesis of trans-cycloalkanopiperidines and cycloalkanopyrrolidines has been achieved via hydroboration of bromocycloalkenes with dichloroboranes.The intermediate bromocycloalkylboronic acids were converted into azidocycloalkylboronates.Addition of two equivalents of boron trichloride in dichloromethane generated dichloroboranes which, by an intramolecular cyclisation gave intermediates 11.These can be readily hydrolyzed to get the corresponding important nitrogen heterocycles in good yields and excellent stereochemical purities.
View MoreNanjing Zelang Medical Technology Co. Ltd
Contact:86-25-83063290/13770714480
Address:Ganjiabian 108# 01 Unit,701-702 room,Yao Hua Street,Qixia District,Nanjing,Jiangsu,China
Contact:+86-371-67759225
Address:No.32, Jinsuo Road, High-tech Zone
Contact:+86-532-80762375
Address:No. 6, Hongkong Middle Road, Qingdao, China
Contact:0086-21-80264647
Address:RM 202, NO 1602 West Zhongshan Rd, Shanghai, China
website:http://www.vanzpharm.com/en/index.html
Contact:86-27-84492310
Address:FANHU INDUSTRY PARK
Doi:10.1021/ic700403d
(2007)Doi:10.1016/j.jorganchem.2007.03.010
(2007)Doi:10.1021/acs.orglett.8b00108
(2018)Doi:10.1016/j.bmc.2007.02.007
(2007)Doi:10.1016/j.ejmech.2013.01.001
(2013)Doi:10.1016/j.bmc.2020.115967
(2021)
