Tetrahedron Letters p. 1265 - 1268 (1993)
Update date:2022-07-30
Topics: Synthesis Stereoselective Hydroboration Experimental
Brown, Herbert C.
Salunkhe, Ashok M.
A highly stereoselective synthesis of trans-cycloalkanopiperidines and cycloalkanopyrrolidines has been achieved via hydroboration of bromocycloalkenes with dichloroboranes.The intermediate bromocycloalkylboronic acids were converted into azidocycloalkylboronates.Addition of two equivalents of boron trichloride in dichloromethane generated dichloroboranes which, by an intramolecular cyclisation gave intermediates 11.These can be readily hydrolyzed to get the corresponding important nitrogen heterocycles in good yields and excellent stereochemical purities.
View Morewebsite:http://www.herbpurify.com
Contact:0086-028-85249238
Address:Room709-C1,Incubator Building, Tianfu Life Science Park No.88,Keyuan Road,Gaoxin district,Chengdu City,Sichuan Prov,China
Hongyi Import & Export CO.,LTD
Contact:86-13319649499
Address:Nanzheng Neighborhood Commitees, Chongwen Office, Yongding District
Contact:+86-22-26358246
Address:601-4-20, Fujiayuan, Tiantai Road, Hebei District, Tianjin, China
Xinchang Jiu Xin Pharmaceutical Co., Ltd
website:http://www.jiuxinpharm.com
Contact:86 137 5756 8585
Address:Poyang industry Park
Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)
Contact:18957018777 +86-570-3888777
Address:The company production base address： Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
Doi:10.1021/ic700403d
(2007)Doi:10.1016/j.jorganchem.2007.03.010
(2007)Doi:10.1021/acs.orglett.8b00108
(2018)Doi:10.1016/j.bmc.2007.02.007
(2007)Doi:10.1016/j.ejmech.2013.01.001
(2013)Doi:10.1016/j.bmc.2020.115967
(2021)
