Novel Antitumor Agents CI-920, PD 113270 and PD 113271. 3. Structure Determination.

Article abstract of DOI:10.1021/jo00204a007

The chemical structures for the novel phosphate-containing antitumor agents CI-920 (1), PD 113270 (2), and PD 113271 (3) were determined by a combination of spectra and chemical means.Extensive analysis of NMR spectral data allowed tentative structures to be assigned for these compounds and their derivatives.These structures were confirmed by reducing CI-920 to 8-methyl-1-octadecanol and by cleaving dephosphorylated CI-920 (7) with sodium periodate to identified products.