Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA

DOI: 10.1016/j.bmcl.2006.11.081

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1386 - 1391 (2007)

Update date:2022-07-29

Topics:

Authors:

Zhao, Zhijian

Wisnoski, David D.

O'Brien, Julie A.

Lemaire, Wei

Williams Jr., David L.

Jacobson, Marlene A.

Wittman, Marion

Ha, Sookhee N.

Schaffhauser, Herve

Sur, Cyrille

Pettibone, Doug J.

Duggan, Mark E.

Conn, P. Jeffrey

Hartman, George D.

Lindsley, Craig W.

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Article abstract of DOI:10.1016/j.bmcl.2006.11.081

This Letter describes, for the first time, the synthesis and SAR, developed through an iterative analog library approach, that led to the discovery of the positive allosteric modulator (PAM) of the metabotropic glutamate receptor mGluR5 CPPHA. Binding to

Full text of DOI:10.1016/j.bmcl.2006.11.081

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