METAL BASED SULFANILAMIDES
1841
8. Chohan, Z.-H., Hassan, M.-U., Khan, K.-M., and
Supuran, C.-T., J. Enz. Inhib. Med. Chem., 2005,
vol. 20, p. 183. doi org/10.1080/14756360500043257
9. Supuran, C.-T., Casini, A., and Scozzafava, A., Med.
Res Rev., 2003, vol. 23, p. 535. doi 10.1002/med.10047
10. Chohan, Z.-H. and Naseer, M.-M., Appl. Organomet.
Chem., 2007, vol. 21, p. 728. doi 10.1002/aoc.1279
11. Owa, T. and Nagasu, T., Exp. Opin. Ther. Patents.,
2000, vol. 10, p. 1725. doi org/10.1517/
13543776.10.11.1725
12. Hassan, M.-U., Chohan, Z.-H., Andrea, S., and Supu-
ran, C.-T., J. Enz. Inhib. Med. Chem., 2004, vol. 19,
p. 263. doi org/10.1080/14756360410001689595
13. Idemudia, O.-G., Sadimenko, A.-P., Afolayan, A.-J.,
and Hosten, E.-C., Bioinorg. Chem. Appl., 2015,
vol. 2015, p. 1. doi org/10.1155/2015/717089
14. Mishra, A.-P., Mishra, R., Jain, R., and Gupta, S.,
Mycobiology, 2012, vol. 40, p. 20. doi org/10.5941/
MYCO.2012.40.1.020
15. Rao, R., Reddy, K.-R., and Mahendra, K.-N., Chem.
Sci. Trans., 2013, vol. 2, p. 1063. doi 10.7598/
cst2013.527
were recorded as percentage of inhibition and com-
pared with standard drugs miconazole and
amphotericin B.
CONCLUSIONS
The synthesized sulfanilamide Schiff bases acted as
bidentate ligands in coordination with Co(II), Ni(II),
Cu(II), and Zn(II) via azomethine-N, thienyl-S, furanyl-O,
and acetyisatin-N. Physical, spectral and analytical
data confirmed that the Schiff bases had octahedral
geometry in the complexes. Antibacterial and
antifungal activities data of the metal complexes
demonstrated higher biological activity against one or
more bacterial and/or fungal strains than non-chelated
ligands. Probably oxygen of furanyl, sulphur of
thioenyl, nitrogen of azomethine, and isatin were the
sites potentially responsible for the enhancement of
antibacterial and antifungal activities.
ACKNOWLEDGMENTS
16. Hyatt, J.-L., Moak, T., Hatfield, M.-J., Tsurkan, L.,
Edwards, C.-C., Wierdl, M., Danks, M.-K., Wadkins, R.-M.,
and Potter, P.-M., J. Med. Chem., 2007, vol. 50,
p. 1876. doi 10.1021/jm061471k
17. Beauchard, A., Ferandin, Y., Frere, S., Lozach, O.,
Blairvacq, M., Meijer, L., Thiéry, V., and Besson, T.,
Bioorg. Med. Chem., 2006, vol. 14, p. 6434. doi
org/10.1016/j.bmc.2006.05.036
The authors are thankful to HEJ research Institute
of Chemistry, University of Karachi, Pakistan, for
providing their help in measuring NMR and mass
spectra and for the help in carrying out antibacterial
and antifungal bioassays.
REFERENCES
18. Prakash, C.-R. and Raja, S., Eur. J. Med. Chem., 2011,
1. Coombs, R.-R., Ringer, M.-K., Blacquiere, J.-M.,
Smith, J.-C., Neilsen, J.-S., Uh, Y.-S, Gilbert, J.-B,
Leger, L.-J, Zhang, H., and Irving, A.-M., Tran. Met.
Chem., 2005, vol. 30, p. 411. doi 10.1007/s11243-004-
7625-4
2. Genc, Y., Ozkanca, R., and Bekdemir, Y., Ann. Clin.
Micro. Antimic., 2008, vol. 7, p. 17. doi 10.1186/1476-
0711-7-17
vol. 46, p. 6057. doi org/10.1016/j.ejmech.2011.10.020
19. Bagihalli, G.-B., Badami, P.-S., and Patil, S.-A., J. Enz.
Inhib. Med. Chem., 2009, vol. 24, p. 381. doi
org/10.1080/14756360802187901
20. Prashanthi, Y. and Raj, S., J. Sci. Res., 2010, vol. 2,
p. 114. doi 10.3329/jsr.v2i1.2732
21. Chohan, Z.-H., Supuran, C.-T., Hadda, T.-B., Nasim, F.-H.,
and Khan, K.-M., J. Enz. Inhib. Med. Chem., 2009,
vol. 24, p. 859. doi 10.1080/14756360802447636
3. Lesch, J.-E., The First Miracle Drugs: How the Sulfa
Drugs Transformed Medicine, New York: Oxford
University Press, 2007, p. 104.
22. Chohan, Z.-H., J. Enz. Inhib. Med. Chem., 2008,
vol. 23, p. 120. doi org/10.1080/14756360701384195
4. Das, M. and Livingstone, S.-E., Br. J. Cancer, 1978,
23. Chohan, Z.-H. and Supuran, C.-T., J .Enz. Inhib. Med.
Chem., 2008, vol. 23, p. 240. doi org/10.1080/
14756360701474913
vol. 37, p. 466. doi 10.1038/bjc.1978.68
5. Ali, M.-A., Mirza, A.-H., Butcher, R.-J., Tarafder, M.-T.-H.,
Keat, T.-B., and Ali, A.-M., J .Inorg. Biochem., 2002,
vol. 92, p. 141. doi org/10.1016/S0162-0134(02)00559-7
6. Anandakumaran, J., Sundararajan, M.-L., Jeyakumar, T.,
and Uddin, M.-N., Am. Chem. Sci. J., 2016, vol. 11,
p. 1. doi 10.9734/ACSJ/2016/22807
7. Scozzafava, A., Owa, T., Mastrolorenzo, A., and
Supuran, C.-T., Curr. Med. Chem., 2003, vol. 10,
p. 925. doi org/10.2174/0929867033457647
24. Nyquist, R.-A., Interpreting Infrared, Raman, and
Nuclear Magnetic Resonance Spectra, Orlando,
Academic Press, 2001.
25. Freeman, R.-A., Handbook of Nuclear Magnetic
Resonance, Longman Publishing, 2nd ed., 1997.
26. Geary, W.-J., Coord. Chem. Rev., 1971, vol. 7, p. 81.
doi org/10.1016/S0010-8545(00)80009-0
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