Bioorganic and Medicinal Chemistry Letters p. 1959 - 1962 (2001)
Update date:2022-08-04
Topics:
DiPardo, Robert M.
Patane, Michael A.
Newton, Randall C.
Price, RoseAnn
Broten, Theodore P.
Chang, Raymond S.L.
Ransom, Richard W.
Di Salvo, Jerry
Freidinger, Roger M.
Bock, Mark G
We disclose a new compound class of potent and selective α-1A adrenergic receptor antagonists exemplified by the geminally, disubstituted cyclic imide 7. The optimization of lead compounds resulting in the cyclic imide motif is highlighted. The results of in vitro and in vivo studies of selected compounds are presented.
View MoreContact:+86-577-65618087-605
Address:Room 402, Unit 4 Xinhu Bldg. Waitan Ruian City, Zhejiang China.
Contact:+86-535-8888888
Address:No.161 Haishi Rd.
Zhejiang Hoshine Silicon Industry Co., Ltd.
Contact:86-573-89179966
Address:Zhapu Town, Pinghu City, Zhejiang, China
Contact:+86-21-6856-1349 523-87676172
Address:No16 . BinJiang Road . Taixing Economy Developing Area .JiangSu Province . China
Hangzhou LINGEBA Technology Co., Ltd.
Contact:+0086-571-87389059
Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
Doi:10.1002/anie.200501363
(2005)Doi:10.1002/chem.200601685
(2007)Doi:10.1002/hlca.19870700518
(1987)Doi:10.1021/ja00293a044
(1985)Doi:10.1016/j.tetlet.2007.06.025
(2007)Doi:10.1002/jccs.202000161
(2020)