Angewandte
Chemie
MALDI spectra of SAMs of alkanethiolates; see: J. Su, M.
chemical screenings that identify small-molecule inhibitors
(or promoters) of protein–protein interactions.[20e]
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Hanley, Langmuir 1998, 14, 1664.
Received: April 20, 2005
Published online: July 29, 2005
[10] GST fusions with src homology domain 3 (GST–SH3) and with
green fluorescent protein (GST–GFP) were assayed with similar
results.
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Keywords: bioinformatics · immobilization ·
.
mass spectrometry · monolayers · proteins
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[8] Both glutathione thiol and benzenesulfonamide thiol were
synthesized in eight steps from commercially available reagents.
1
All intermediates gave satisfactory H NMR spectra. Synthetic
schemes and experimental details are provided in the Supporting
Information.
[9] The peak at m/z 693.6 was derived from a symmetric disulfide of
tri(ethylene glycol)-terminated alkanethiolates. Sodium adducts
of disulfides are the major species, which are observed in
Angew. Chem. Int. Ed. 2005, 44, 5480 –5483
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