Asymmetric diels-alder cycloaddition of 1-aminocyclohexadiene to chiral acrylate: Synthesis of enantiopure bridgehead-aminobicyclo[2.2.2]octane-2- carboxylic acid derivatives

Article abstract of DOI:10.1002/ejoc.200700236

The acrylate derivative of the (R)-4-(3-hydroxy-4,4-dimethyl-2- oxopyrrolidin-1-yl)benzoic acid benzyl ester (R)-2 reacted with 1-(benzyloxycarbonylamino)cyclohexadiene 3 under microwave irradation in solvent-free conditions to yield [4+2] cycloadducts in