Tsuji–Trost Reaction of Non-Derivatized Allylic Alcohols

Article abstract of DOI:10.1002/chem.201705164

Palladium-catalyzed allylic substitution of non-derivatized enantioenriched allylic alcohols with a variety of uncharged N-, S-, C- and O-centered nucleophiles using a bidentate BiPhePhos ligand is described. A remarkable effect of the counter ion (X) of the XPd[κ²-BiPhePhos][η³-C₃H₅] was observed. When ClPd[κ²-BiPhePhos][η³-C₃H₅] (complex I) was used as catalyst, non-reproducible results were obtained. Study of the complex by X-ray crystallography, ³¹P NMR spectroscopy, and ESI-MS showed that a decomposition occurred where one of the phosphite ligands was oxidized to the corresponding phosphate, generating ClPd[κ¹-BiPhePhosphite-phosphate][η³-C₃H₅] species (complex II). When the chloride was exchanged to the weaker coordinating OTf^? counter ion the more stable Pd[κ²-BiPhePhos][η³-C₃H₅]⁺+[OTf] ^? (complex III) was formed. Complex III performed better and gave higher enantiospecificities in the substitution reactions. Complex III was evaluated in Tsuji–Trost reactions of stereogenic non-derivatized allylic alcohols. The desired products were obtained in good to excellent yields (71–98 %) and enantiospecificities (73–99 %) for both inter- and intramolecular substitution reactions with only water generated as a by-product. The methodology was applied to key steps in total synthesis of (S)-cuspareine and (+)-lentiginosine. A reaction mechanism involving a palladium hydride as a key intermediate in the activation of the hydroxyl group is proposed in the overall transformation.