Bioorganic and Medicinal Chemistry Letters p. 5210 - 5213 (2007)
Update date:2022-08-05
Topics:
Yang, Hua
Hu, Gao-Yun
Chen, Jun
Wang, Yi
Wang, Zhong-Hua
A series of 3-substituted-1(3H)-isobenzofuranone 6a-g and 7a-g were synthesized from phthalic anhydride. The compound 6a-g was resolved. The antiplatelet activities of these compounds were evaluated using in vitro experiment of platelet aggregation. The levels of antiplatelet activity were displayed as following sequence: l-isomer > dl-isomer > d-isomer, respectively. The alkylphthalide is more active than the corresponding alkenephthalide. All these compounds were less active than n-butylphthalide (NBP, 6c) and Aspirin (Asp).
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