A CONVENIENT SYNTHESIS OF 1,2,3,4-TETRAHYDROISOQUINOLIN-3-ONES AND EVIDENCE FOR THE PARTICIPATION OF A QUINONE METHIDE INTERMEDIATE IN THE THERMOLYSIS OF MIXTURES OF ISOCHROMAN-3-ONES AND UREAS

Article abstract of DOI:10.1016/S0040-4020(01)98813-1

Evidence is presented to indicate that quinone methides are formed when isochroman-3-ones are heated.In the presence of ureas these intermediates react to yield, 1,2,3,4-tetrahydroisoquinolin-3-ones thus enabling rapid access to 4-benzyl-1,2,3,4-tetrahydr