O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors

DOI: 10.1016/j.bmcl.2009.08.030

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5632 - 5635 (2009)

Update date:2022-08-05

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Authors:

Xu, Baihua

Lv, Binhua

Feng, Yan

Xu, Ge Xu, Ge

Du, Jiyan

Welihinda, Ajith

Sheng, Zelin

Seed, Brian

Chen, Yuanwei

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Article abstract of DOI:10.1016/j.bmcl.2009.08.030

Two series of O-spiro C-aryl glucosides were synthesized and tested for inhibition of hSGLT1 and hSGLT2. 6′-O-Spiro C-aryl glucosides exhibited potent in vitro hSGLT2 inhibitory activity but 2′-O-spiro C-aryl glucosides showed no in vitro hSGLT2 inhibitory activity at a screening concentration of 1 μM.

Full text of DOI:10.1016/j.bmcl.2009.08.030

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