Synthesis of D-galactopyranosylphosphonic and (D-galactopyranosylmethyl) phosphonic acids as intermediates of inhibitors of galactosyltransferases

Article abstract of DOI:10.1135/cccc20061659

Employing the Michaelis-Arbuzov reaction of 1-O-acetyl-2,3,4,6-tetra-O- benzyl-D-galactopyranose with triethyl phosphite and trimethylsilyl trifluoromethanesulfonate, α- and β-D-galactopyranosylphosphonic acids were prepared in 33 and 28% yields, respecti