Synthesis and identification of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β, 4′-oxazole] analogs with dissociated antiprogesterone activities

Article abstract of DOI:10.1016/j.bmcl.2007.08.064

A series of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β, 4′-oxazole] analogs have been evaluated for their antagonist hormonal properties using the T47D cell-based alkaline phosphatase assay and the A549 cell-based functional assay. Some of the