Journal of the Chemical Society. Perkin transactions I p. 1013 - 1019 (1984)
Update date:2022-08-05
Topics:
Copeland, R. Jeffrey
Hill, Robert A.
Hinchcliffe, David J.
Staunton, James
Incorporation studies with 14C-labelled acetates and malonate confirm the polyketide origin of aspyrone (1), and identify the chain starter unit.Five carbons are derived from the methyl group of acetate, and the remaining four from the carboxy group.The pattern of incorporation of tritium from <2-3H>acetate is inconsistent with a biosynthesis from aromatic precursors of the mellein type.Possibly advanced precursors containing a 2-methylchromone nucleus were not incorporated.The evidence suggests that aromatic precursors are not involved in aspyrone biosynthesis, and that the carbon skeleton is produced like that of the co-metabolite asperlactone (6), by decarboxylation and rearrangement of a linear pentaketide intermediate.
View MoreWeifang Jahwa Chemical Co.,Ltd
Contact:0086-536-8897731,8897730
Address:No.5166 East Dongfeng Street,Weifang,Shandong,China
Jinan Kaypharm Chemical Co.,Ltd
Contact:86-0531-86986780
Address:Room101,No189-2,Huayuan Road,Jinan City,Shandong Province
NINGBO PANGS CHEM INT’L CO.,LTD.
Contact:+86-574-27666845
Address:FLOOR 21,BUILDING NO.11,XIN TIAN DI,NO.689 SHI JI ROAD,NINGBO CHINA
Luzhou North Chemical Co., Ltd.
Contact:+86-830-2796784；+86-830-2796776
Address:Gaoba, Longmatan District, Luzhou, Sichuan Province
Dongtai Xinyuan Chemical Co., Ltd.
Contact:+86-21-56733000
Address:404F, 99Nong No.117 Zhongtan Rd. Shanghai
Doi:10.1016/j.bmc.2007.09.003
(2007)Doi:10.1021/jo01068a013
(1961)Doi:10.1016/j.molstruc.2020.129365
(2021)Doi:10.1021/jacs.0c00727
(2020)Doi:10.1016/j.bmcl.2007.09.057
(2007)Doi:10.1016/j.tetlet.2015.10.108
(2015)
