Synthesis and Characterization of DNA Oligomers and Duplexes Containing Covalently Attached Molecular Labels: Comparison of Biotin, Fluorescein, and Pyrene Labels by Thermodynamic and Optical Spectroscopic Measurements

Article abstract of DOI:10.1021/ja00200a011

A series of oligonucleotides having the base sequence 5'-GCA(C^*-L)(T^*-L)CAG-3' have been synthesized where C^* and T^* respectively a chemically modified cytidine or thymidine base containing a linker arm terminat