Tetracyclic pyridazines as potential psychopharmacological agents

Article abstract of DOI:10.1021/jm00145a005

Since the Z isomer of chlorprothixene is far more active than its E counterpart, it was of interest to develop a stereoselective synthesis for this class of compounds. Insertion of a benzenesulfonamido group at the peri position of a chlorprothixene precu