
Journal of Organic Chemistry p. 2601 - 2603 (1985)
Update date:2022-09-26
Topics: Synthesis Peptides Azides Experimental
Zaloom, Jeffrey
Calandra, Michael
Roberts, David C.
The title reaction, in which an azido compound is treated first with a tertiary phosphine, followed by warming in an inert solvent with a carboxylic acid, has been used to synthesize a number of small peptides and appears from mechanistic studies to proceed via a pentacoordinate phosphorus intermediate.
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