Analogues of Platelet Activating Factor (PAF). 2. Some Modifications of the Glycerine Backbone

Article abstract of DOI:10.1021/jm00147a010

Racemic analogues of platelet activating factor (PAF) that contain a methylene group between the C₂ and C₃ carbon atoms (39) or between the C₁ and C₂ carbon atoms (40) have been synthesized.These compounds show reduced platelet aggregation and hypotensive activity as measured against racemic C₁₆ PAF.Compounds in which the C₁ carbon atom of PAF is substituted with one or two methyl groups (41 and 42, respectively) or the C₃ carbon is substituted with a single methyl group (43) have been synthesized.Platelet aggregation and hypotensive responses producedby these compounds are significantly less than those obtained with racemic C₁₆ PAF.None of the above compounds exhibit a separation of the platelet aggregation and hypotensive activities.